Regardless of Feature Size (RFS) is the default condition of all geometric tolerances by rule #2 of Geometric Dimensioning and Tolerancing and requires no callout. Regardless of feature size simply means that whatever GD&T callout you make, is controlled independently of the size dimension of the part.
This rule can be overridden by Maximum Material Condition or Least Material Condition, which specify the GD&T conditions at the Max or Min size of the part. LMC or MMC must be called out on the drawing specifically though to eliminate the regardless of feature size default.
For simplicity, the definitions of all the GD&T symbols are by default, stated as Regardless of Feature Size. For most geometric symbols besides those that allow maximum material condition, RFS can never be overridden. Regardless of feature size eliminates any potential bonus tolerance, allowing the GD&T tolerances to be more tightly controlled.
Since Regardless of feature size is the default condition it is used always and ignored only when specified. It is applied for most part conditions. RFS is always kept where balance is critical and where both sides of the tolerance must be maintained independently of the GD&T callouts.
Regardless of Feature size requires the axis to be measured separately from the size of the hole and cannot be gauged easily. However, there is no bonus tolerance allowed in this condition so the perpendicularity would be much better controlled regardless of the size of the hole.
In the following example, no material modifiers are called out, RFS would be implied and the control for the parts would be like this:
This of course makes sense and follows the normal rules of Geometric Dimensioning and Tolerancing. However if you were to add a Max Material Condition to the drawing, the hole limits are quite different. If you were to control perpendicularity of an axis with MMC, you could control and gauge the part according to Example 2 from our perpendicularity page:
There is now a bonus tolerance that is added to the perpendicularity tolerance to make it larger. With Regardless of feature size this could not happen, as the perpendicularity would have to be the same, regardless of the features size. This is a fairly advanced concept and is better explained in our section on Bonus Tolerances (coming soon).
Gauging and measurement would apply as normal for this condition for any GD&T symbol. All GD&T callouts must be measured independently from the size of the part.